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Aciphex uses: Rabeprazole / Aciphex is a proton pump inhibitor (PPI) used to treat certain conditions in which there is too much acid in the stomach. It is used to treat duodenal ulcers and gastro-esophageal reflux disease (GERD), a condition in which the acid in the stomach washes back up into the esophagus. Rabeprazole / Aciphex is also used to treat Zollinger-Ellison disease, a condition in which the stomach produces too much acid.

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