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P Glitz uses: Pioglitazone is an oral diabetes medicine that help control blood sugar levels. Pioglitazone is for people with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes. Pioglitazone (pye-oh-GLI-ta-zone) is used to treat a certain type of diabetes mellitus (sugar diabetes) called type 2 diabetes. It may be used alone, with insulin, or with metformin or another type of oral diabetes medicine called a sulfonylurea. Pioglitazone is indicated as an adjunct to diet and exercise as a once-daily combination therapy to improve glycemic control in patients with type 2 diabetes who are already treated with a combination of pioglitazone and a sulfonylurea or whose diabetes is not adequately controlled with a sulfonylurea alone, or for those patients who have initially responded to pioglitazone alone and require additional glycemic control. Management of type 2 diabetes should also include nutritional counseling, weight reduction as needed, and exercise. These efforts are important not only in the primary< treatment of type 2 diabetes, but also to maintain the efficacy of drug therapy.